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TPM3 (Tropomyosin alpha-3 chain) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Lung cancer, Colorectal cancer and Non-small-cell lung cancer.
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon.
Open Targets scores its association with cancer at 0.72 (direct and indirect evidence; datatypes literature 0.96, affected pathway 0.76, genetic association 0.09, somatic mutation 0.97).
In plain words · TPM3 (Tropomyosin alpha-3 chain) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Lung cancer, Colorectal cancer and Non-small-cell lung cancer.
TPM3 (Tropomyosin alpha-3 chain) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Lung cancer, Colorectal cancer and Non-small-cell lung cancer.
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction.
No product in this corpus aims at TPM3 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1986. Earliest sequence paper UniProt cites for the protein: Reinach F.C. et al, Nature, 1986, "Tissue-specific expression of the human tropomyosin gene involved in the generation of the trk oncogene". Source.
Sources: HGNC HGNC:12012 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P06753 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000143549 (association with cancer (MONDO_0004992) 0.72; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.50, colorectal cancer 0.50, lung cancer 0.52 (GraphQL API, CC0))
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilising cytoskeleton actin filaments. Location: Cytoplasm, cytoskeleton (UniProt). Locus 1q21.3 (HGNC).
Query for this target: (TITLE:"TPM3" OR ABSTRACT:"TPM3" OR TITLE:"tropomyosin 3" OR ABSTRACT:"tropomyosin 3" OR TITLE:"Tropomyosin alpha-3 chain" OR ABSTRACT:"Tropomyosin alpha-3 chain" OR TITLE:"NEM1" OR ABSTRACT:"NEM1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TPM3, not a curated reading list.