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TPM3 (Tropomyosin alpha-3 chain) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Lung cancer, Colorectal cancer and Non-small-cell lung cancer. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilising cytoskeleton actin filaments. Location: Cytoplasm, cytoskeleton (UniProt). Locus 1q21.3 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"TPM3" OR ABSTRACT:"TPM3" OR TITLE:"tropomyosin 3" OR ABSTRACT:"tropomyosin 3" OR TITLE:"Tropomyosin alpha-3 chain" OR ABSTRACT:"Tropomyosin alpha-3 chain" OR TITLE:"NEM1" OR ABSTRACT:"NEM1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TPM3, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/tpm3.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/tpm3.json. Licence CC BY-NC 4.0.