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TOX3 (TOX high mobility group box family member 3) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
Transcriptional coactivator of the p300/CBP-mediated transcription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts.
Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.72).
In plain words · TOX3 (TOX high mobility group box family member 3) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
TOX3 (TOX high mobility group box family member 3) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
Transcriptional coactivator of the p300/CBP-mediated transcription complex. Activates transactivation through cAMP response element (CRE) sites.
No product in this corpus aims at TOX3 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1997. Earliest sequence paper UniProt cites for the protein: Margolis R.L. et al, Hum. Genet, 1997, "cDNAs with long CAG trinucleotide repeats from human brain". Source.
Sources: HGNC HGNC:11972 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O15405 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000103460 (association with cancer (MONDO_0004992) 0.58; per-cancer scores at or above 0.5: breast cancer 0.57 (GraphQL API, CC0))
Transcriptional coactivator of the p300/CBP-mediated transcription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the oestrogen-responsive or BCL-2 promoters. Required for depolarisation-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the oestrogen-responsive C3 promoter region. Location: Nucleus (UniProt). Locus 16q12.1 (HGNC).
Query for this target: (TITLE:"TOX3" OR ABSTRACT:"TOX3" OR TITLE:"TOX high mobility group box family member 3" OR ABSTRACT:"TOX high mobility group box family member 3" OR TITLE:"CAGF9" OR ABSTRACT:"CAGF9" OR TITLE:"TNRC9" OR ABSTRACT:"TNRC9") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TOX3, not a curated reading list.