Loading
TOX3 (TOX high mobility group box family member 3) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Transcriptional coactivator of the p300/CBP-mediated transcription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the oestrogen-responsive or BCL-2 promoters. Required for depolarisation-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the oestrogen-responsive C3 promoter region. Location: Nucleus (UniProt). Locus 16q12.1 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"TOX3" OR ABSTRACT:"TOX3" OR TITLE:"TOX high mobility group box family member 3" OR ABSTRACT:"TOX high mobility group box family member 3" OR TITLE:"CAGF9" OR ABSTRACT:"CAGF9" OR TITLE:"TNRC9" OR ABSTRACT:"TNRC9") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TOX3, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/tox3.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/tox3.json. Licence CC BY-NC 4.0.