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TIMP1 (Metalloproteinase inhibitor 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14.
CIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Fulvestrant and Paclitaxel.
In plain words · TIMP1 (Metalloproteinase inhibitor 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
TIMP1 (Metalloproteinase inhibitor 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor.
No product in this corpus aims at TIMP1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA TIMP1: RNA tissue enhanced (blood vessel 2,943 nTPM); no normal tissue stained high; highest cancer staining breast cancer (1 of 11 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Breast cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas TIMP1 tissue; Open Targets ENSG00000102265 associations
First described 1985. Earliest sequence paper UniProt cites for the protein: Docherty A.J.P. et al, Nature, 1985, "Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity". Source.
Sources: HGNC HGNC:11820 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P01033 (protein name, function text, keywords and locations (REST API)); CIViC gene TIMP1 (2 evidence items, 0 assertions, 1 variants; diseases: Breast Cancer (GraphQL API, CC0))
Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signalling cascades via CD63 and ITGB1. Plays a role in integrin signalling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Location: Secreted (UniProt). Locus Xp11.3 (HGNC).
RNA: tissue enhanced (blood vessel 2,943 nTPM), detected in all normal tissues.
No normal tissue stained high.
Medium only: carcinoid, endometrial cancer, lung cancer, melanoma.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"TIMP1" OR ABSTRACT:"TIMP1" OR TITLE:"TIMP metallopeptidase inhibitor 1" OR ABSTRACT:"TIMP metallopeptidase inhibitor 1" OR TITLE:"Metalloproteinase inhibitor 1" OR ABSTRACT:"Metalloproteinase inhibitor 1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TIMP1, not a curated reading list.