{"entity":{"id":"timp1","kind":"target","name":"TIMP1","aka":["TIMP metallopeptidase inhibitor 1","Metalloproteinase inhibitor 1"],"tldr":"TIMP1 (Metalloproteinase inhibitor 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.","summary":"Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14.\n\nCIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Fulvestrant and Paclitaxel.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11820","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11820"},{"label":"UniProt P01033","url":"https://www.uniprot.org/uniprotkb/P01033/entry"},{"label":"NCBI Gene 7076","url":"https://www.ncbi.nlm.nih.gov/gene/7076"},{"label":"Ensembl ENSG00000102265","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000102265"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TIMP1","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:11820","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11820","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P01033","url":"https://www.uniprot.org/uniprotkb/P01033/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene TIMP1","url":"https://civicdb.org/features/5777","note":"2 evidence items, 0 assertions, 1 variants; diseases: Breast Cancer (GraphQL API, CC0)"}],"distribution":"one-type","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA TIMP1: RNA tissue enhanced (blood vessel 2,943 nTPM); no normal tissue stained high; highest cancer staining breast cancer (1 of 11 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Breast cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas TIMP1 tissue","url":"https://www.proteinatlas.org/ENSG00000102265-TIMP1/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000102265 associations","url":"https://platform.opentargets.org/target/ENSG00000102265/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:11820","ensembl":"ENSG00000102265","uniprot":"P01033","entrez":"7076","firstDescribed":1985,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Docherty A.J.P. et al, Nature, 1985, \"Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/3903517/","biology":"Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signalling cascades via CD63 and ITGB1. Plays a role in integrin signalling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Location: Secreted (UniProt). Locus Xp11.3 (HGNC).","whereFound":["Breast cancer: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/timp1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"}]}}