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THBS2 (Thrombospondin-2) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · THBS2 (Thrombospondin-2) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
THBS2 (Thrombospondin-2) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.
No product in this corpus aims at THBS2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA THBS2: RNA tissue enhanced (blood vessel 160 nTPM); no normal tissue stained high; highest cancer staining colorectal cancer (1 of 10 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Colorectal cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas THBS2 tissue; Open Targets ENSG00000186340 associations
First described 1992. Earliest sequence paper UniProt cites for the protein: Labell T.L. et al, Genomics, 1992, "Thrombospondin II: partial cDNA sequence, chromosome location, and expression of a second member of the thrombospondin gene family in humans". Source.
Sources: HGNC HGNC:11786 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P35442 (protein name, function text, keywords and locations (REST API)); CIViC gene THBS2 (1 evidence items, 0 assertions, 1 variants; diseases: Colorectal Cancer (GraphQL API, CC0))
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties. Locus 6q27 (HGNC).
RNA: tissue enhanced (blood vessel 160 nTPM), detected in many normal tissues.
No normal tissue stained high; medium in Adipose tissue, Adrenal gland, Appendix, Breast, Bronchus, Caudate and more.
Medium only: breast cancer, carcinoid, cervical cancer, endometrial cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"THBS2" OR ABSTRACT:"THBS2" OR TITLE:"thrombospondin 2" OR ABSTRACT:"thrombospondin 2" OR TITLE:"Thrombospondin-2" OR ABSTRACT:"Thrombospondin-2" OR TITLE:"TSP2" OR ABSTRACT:"TSP2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about THBS2, not a curated reading list.