{"entity":{"id":"thbs2","kind":"target","name":"THBS2","aka":["thrombospondin 2","Thrombospondin-2","TSP2"],"tldr":"THBS2 (Thrombospondin-2) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.","summary":"Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11786","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11786"},{"label":"UniProt P35442","url":"https://www.uniprot.org/uniprotkb/P35442/entry"},{"label":"NCBI Gene 7058","url":"https://www.ncbi.nlm.nih.gov/gene/7058"},{"label":"Ensembl ENSG00000186340","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000186340"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"THBS2","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:11786","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11786","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P35442","url":"https://www.uniprot.org/uniprotkb/P35442/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene THBS2","url":"https://civicdb.org/features/5761","note":"1 evidence items, 0 assertions, 1 variants; diseases: Colorectal Cancer (GraphQL API, CC0)"}],"distribution":"one-type","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA THBS2: RNA tissue enhanced (blood vessel 160 nTPM); no normal tissue stained high; highest cancer staining colorectal cancer (1 of 10 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Colorectal cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas THBS2 tissue","url":"https://www.proteinatlas.org/ENSG00000186340-THBS2/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000186340 associations","url":"https://platform.opentargets.org/target/ENSG00000186340/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:11786","ensembl":"ENSG00000186340","uniprot":"P35442","entrez":"7058","firstDescribed":1992,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Labell T.L. et al, Genomics, 1992, \"Thrombospondin II: partial cDNA sequence, chromosome location, and expression of a second member of the thrombospondin gene family in humans\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/1559694/","biology":"Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties. Locus 6q27 (HGNC).","whereFound":["Colorectal cancer: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/thbs2/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}]}}