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TGFA (Protransforming growth factor alpha) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Head and neck squamous cell carcinoma.
TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.76, animal model 0.69, genetic association 0.00).
In plain words · TGFA (Protransforming growth factor alpha) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Head and neck squamous cell carcinoma.
TGFA (Protransforming growth factor alpha) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Head and neck squamous cell carcinoma.
TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
No product in this corpus aims at TGFA yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA TGFA: RNA tissue enhanced (brain 25 nTPM, esophagus 24 nTPM); blood lineage lineage enriched (granulocytes 24 nTPM); no normal tissue stained high; highest cancer staining head and neck cancer (1 of 4 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Head and neck squamous cell carcinoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas TGFA tissue; Open Targets ENSG00000163235 associations
First described 1984. Earliest sequence paper UniProt cites for the protein: Derynck et al, Cell, 1984, "Human transforming growth factor-alpha: precursor structure and expression in E. coli". Source.
Sources: HGNC HGNC:11765 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P01135 (protein name, function text, keywords and locations (REST API)); CIViC gene TGFA (1 evidence items, 0 assertions, 1 variants; diseases: Head And Neck Squamous Cell Carcinoma (GraphQL API, CC0)); Open Targets ENSG00000163235 (association with cancer (MONDO_0004992) 0.50; (GraphQL API, CC0))
TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. Location: Secreted, extracellular space; Cell membrane (UniProt). Locus 2p13.3 (HGNC).
RNA: tissue enhanced (brain 25 nTPM, esophagus 24 nTPM), detected in many normal tissues. Blood: lineage enriched (granulocytes 24 nTPM).
No normal tissue stained high; medium in Adrenal gland, Appendix, Breast, Caudate, Cerebral cortex, Cervix and more.
RNA cancer enhanced: Kidney Renal Clear Cell Carcinoma 63 pTPM.
Medium only: breast cancer, carcinoid, cervical cancer, colorectal cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"TGFA" OR ABSTRACT:"TGFA" OR TITLE:"transforming growth factor alpha" OR ABSTRACT:"transforming growth factor alpha" OR TITLE:"Protransforming growth factor alpha" OR ABSTRACT:"Protransforming growth factor alpha") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TGFA, not a curated reading list.
Shares Renal cell carcinoma (KEGG map), CIViC, Open Targets Platform.
Shares Renal cell carcinoma (KEGG map), CIViC, Open Targets Platform.