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TFF3 (Trefoil factor 3) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen).
CIViC holds 1 clinical evidence item and 0 assertions across 2 variants, naming Tamoxifen and Aminoglutethimide.
In plain words · TFF3 (Trefoil factor 3) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
TFF3 (Trefoil factor 3) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen).
No product in this corpus aims at TFF3 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA group enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA TFF3: RNA group enriched (cervix 434 nTPM, intestine 510 nTPM, salivary gland 534 nTPM); blood lineage lineage enriched (granulocytes 2 nTPM); high antibody staining in 7 normal tissues; highest cancer staining endometrial cancer (3 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Breast cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas TFF3 tissue; Open Targets ENSG00000160180 associations
First described 1993. Earliest sequence paper UniProt cites for the protein: Hauser et al, Proc. Natl. Acad. Sci. U.S.A, 1993, "hP1.B, a human P-domain peptide homologous with rat intestinal trefoil factor, is expressed also in the ulcer-associated cell lineage and the uterus". Source.
Sources: HGNC HGNC:11757 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q07654 (protein name, function text, keywords and locations (REST API)); CIViC gene TFF3 (1 evidence items, 0 assertions, 2 variants; diseases: Breast Cancer (GraphQL API, CC0))
Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen). Location: Secreted, extracellular space, extracellular matrix; Cytoplasm (UniProt). Locus 21q22.3 (HGNC).
RNA: group enriched (cervix 434 nTPM, intestine 510 nTPM, salivary gland 534 nTPM, thyroid gland 559 nTPM), detected in many normal tissues. Blood: lineage enriched (granulocytes 2 nTPM).
RNA cancer enhanced: Colon Adenocarcinoma 718 pTPM.
Medium only: cervical cancer, colorectal cancer, lung cancer, pancreatic cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"TFF3" OR ABSTRACT:"TFF3" OR TITLE:"trefoil factor 3" OR ABSTRACT:"trefoil factor 3" OR TITLE:"Trefoil factor 3" OR ABSTRACT:"Trefoil factor 3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TFF3, not a curated reading list.