{"entity":{"id":"tff3","kind":"target","name":"TFF3","aka":["trefoil factor 3","Trefoil factor 3"],"tldr":"TFF3 (Trefoil factor 3) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.","summary":"Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen).\n\nCIViC holds 1 clinical evidence item and 0 assertions across 2 variants, naming Tamoxifen and Aminoglutethimide.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11757","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11757"},{"label":"UniProt Q07654","url":"https://www.uniprot.org/uniprotkb/Q07654/entry"},{"label":"NCBI Gene 7033","url":"https://www.ncbi.nlm.nih.gov/gene/7033"},{"label":"Ensembl ENSG00000160180","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000160180"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TFF3","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:11757","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11757","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q07654","url":"https://www.uniprot.org/uniprotkb/Q07654/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene TFF3","url":"https://civicdb.org/features/5737","note":"1 evidence items, 0 assertions, 2 variants; diseases: Breast Cancer (GraphQL API, CC0)"}],"distribution":"one-type","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA group enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA TFF3: RNA group enriched (cervix 434 nTPM, intestine 510 nTPM, salivary gland 534 nTPM); blood lineage lineage enriched (granulocytes 2 nTPM); high antibody staining in 7 normal tissues; highest cancer staining endometrial cancer (3 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Breast cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas TFF3 tissue","url":"https://www.proteinatlas.org/ENSG00000160180-TFF3/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000160180 associations","url":"https://platform.opentargets.org/target/ENSG00000160180/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:11757","ensembl":"ENSG00000160180","uniprot":"Q07654","entrez":"7033","firstDescribed":1993,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Hauser et al, Proc. Natl. Acad. Sci. U.S.A, 1993, \"hP1.B, a human P-domain peptide homologous with rat intestinal trefoil factor, is expressed also in the ulcer-associated cell lineage and the uterus\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/8346203/","biology":"Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen). Location: Secreted, extracellular space, extracellular matrix; Cytoplasm (UniProt). Locus 21q22.3 (HGNC).","whereFound":["Breast cancer: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/tff3/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"}]}}