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TF (Serotransferrin) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Melanoma.
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilisation. Serum transferrin may also have a further role in stimulating cell proliferation.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Vemurafenib.
In plain words · TF (Serotransferrin) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Melanoma.
TF (Serotransferrin) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Melanoma.
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.
No product in this corpus aims at TF yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA group enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA TF: RNA group enriched (liver 7,020 nTPM, retina 2,257 nTPM); high antibody staining in 1 normal tissue. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Skin cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas TF tissue; Open Targets ENSG00000091513 associations
First described 1983. Earliest sequence paper UniProt cites for the protein: McGillivray R.T.A. et al, J. Biol. Chem, 1983, "The primary structure of human serum transferrin. The structures of seven cyanogen bromide fragments and the assembly of the complete structure". Source.
Sources: HGNC HGNC:11740 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P02787 (protein name, function text, keywords and locations (REST API)); CIViC gene TF (1 evidence items, 0 assertions, 1 variants; diseases: Melanoma (GraphQL API, CC0))
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilisation. Serum transferrin may also have a further role in stimulating cell proliferation. Location: Secreted (UniProt). Locus 3q22.1 (HGNC).
RNA: group enriched (liver 7,020 nTPM, retina 2,257 nTPM), detected in all normal tissues.
Medium: Duodenum, Small intestine.
RNA cancer enriched: Liver Hepatocellular Carcinoma 1,360 pTPM.
No cancer stained high; medium in breast cancer, carcinoid, cervical cancer, colorectal cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"TF" OR ABSTRACT:"TF" OR TITLE:"transferrin" OR ABSTRACT:"transferrin" OR TITLE:"Serotransferrin" OR ABSTRACT:"Serotransferrin" OR TITLE:"PRO1557" OR ABSTRACT:"PRO1557" OR TITLE:"PRO2086" OR ABSTRACT:"PRO2086") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TF, not a curated reading list.