{"entity":{"id":"tf","kind":"target","name":"TF","aka":["transferrin","Serotransferrin","PRO1557","PRO2086"],"tldr":"TF (Serotransferrin) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Melanoma.","summary":"Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilisation. Serum transferrin may also have a further role in stimulating cell proliferation.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Vemurafenib.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11740","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11740"},{"label":"UniProt P02787","url":"https://www.uniprot.org/uniprotkb/P02787/entry"},{"label":"NCBI Gene 7018","url":"https://www.ncbi.nlm.nih.gov/gene/7018"},{"label":"Ensembl ENSG00000091513","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000091513"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TF","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:11740","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11740","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P02787","url":"https://www.uniprot.org/uniprotkb/P02787/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene TF","url":"https://civicdb.org/features/5723","note":"1 evidence items, 0 assertions, 1 variants; diseases: Melanoma (GraphQL API, CC0)"}],"distribution":"one-type","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA group enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA TF: RNA group enriched (liver 7,020 nTPM, retina 2,257 nTPM); high antibody staining in 1 normal tissue. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Skin cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas TF tissue","url":"https://www.proteinatlas.org/ENSG00000091513-TF/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000091513 associations","url":"https://platform.opentargets.org/target/ENSG00000091513/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:11740","ensembl":"ENSG00000091513","uniprot":"P02787","entrez":"7018","firstDescribed":1983,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: McGillivray R.T.A. et al, J. Biol. Chem, 1983, \"The primary structure of human serum transferrin. The structures of seven cyanogen bromide fragments and the assembly of the complete structure\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/6833213/","biology":"Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilisation. Serum transferrin may also have a further role in stimulating cell proliferation. Location: Secreted (UniProt). Locus 3q22.1 (HGNC).","whereFound":["Melanoma: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/tf/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"}]}}