Loading
TBXT (T-box transcription factor T) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Chordoma.
Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence and activates gene transcription when bound to such a site.
CIViC holds 5 clinical evidence items and 0 assertions across 3 variants, naming Nivolumab. In OnCo, 1 product record names it (GI-6301).
In plain words · TBXT (T-box transcription factor T) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Chordoma.
TBXT (T-box transcription factor T) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Chordoma.
Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence and activates gene transcription when bound to such a site.
No product in this corpus aims at TBXT yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Tumour-associated overexpression: HPA finds the RNA cancer enriched in cancer (Testicular Germ Cell Tumor (TCGA)) and group enriched in normal parathyroid gland, pituitary gland, so the tumour and the normal tissue it comes from share the target and the medicine relies on the difference in level. HPA TBXT: RNA group enriched (parathyroid gland 2 nTPM, pituitary gland 1 nTPM); no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Sarcomas (soft tissue, bone, GIST)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas TBXT tissue; Human Protein Atlas TBXT pathology; Open Targets ENSG00000164458 associations
First described 1996. Earliest sequence paper UniProt cites for the protein: Edwards Y.H. et al, Genome Res, 1996, "The human homolog T of the mouse T(Brachyury) gene; gene structure, cDNA sequence, and assignment to chromosome 6q27". Source.
Sources: HGNC HGNC:11515 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O15178 (protein name, function text, keywords and locations (REST API)); CIViC gene TBXT (5 evidence items, 0 assertions, 3 variants; diseases: Chordoma, Poorly Differentiated Chordoma (GraphQL API, CC0))
Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence and activates gene transcription when bound to such a site. Location: Nucleus (UniProt). Locus 6q27 (HGNC).
RNA: group enriched (parathyroid gland 2 nTPM, pituitary gland 1 nTPM), detected in some normal tissues.
No normal tissue stained high.
RNA cancer enriched: Testicular Germ Cell Tumor 10 pTPM.
No cancer stained high; medium in lymphoma.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"TBXT" OR ABSTRACT:"TBXT" OR TITLE:"T-box transcription factor T" OR ABSTRACT:"T-box transcription factor T") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TBXT, not a curated reading list.
Shares Poorly differentiated chordoma (SMARCB1-deficient), CIViC.
Shares Poorly differentiated chordoma (SMARCB1-deficient), Chordoma.