{"entity":{"id":"tbxt","kind":"target","name":"TBXT","aka":["T-box transcription factor T"],"tldr":"TBXT (T-box transcription factor T) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Chordoma.","summary":"Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence and activates gene transcription when bound to such a site.\n\nCIViC holds 5 clinical evidence items and 0 assertions across 3 variants, naming Nivolumab. In OnCo, 1 product record names it (GI-6301).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11515","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11515"},{"label":"UniProt O15178","url":"https://www.uniprot.org/uniprotkb/O15178/entry"},{"label":"NCBI Gene 6862","url":"https://www.ncbi.nlm.nih.gov/gene/6862"},{"label":"Ensembl ENSG00000164458","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000164458"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["chordoma"],"sections":[],"technologies":[],"targets":[],"drugs":["gi-6301"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 5 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Poorly Differentiated Chordoma."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TBXT","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:11515","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11515","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O15178","url":"https://www.uniprot.org/uniprotkb/O15178/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene TBXT","url":"https://civicdb.org/features/5581","note":"5 evidence items, 0 assertions, 3 variants; diseases: Chordoma, Poorly Differentiated Chordoma (GraphQL API, CC0)"}],"specificity":"tumour-associated","distribution":"one-type","specificityNote":"Tumour-associated overexpression: HPA finds the RNA cancer enriched in cancer (Testicular Germ Cell Tumor (TCGA)) and group enriched in normal parathyroid gland, pituitary gland, so the tumour and the normal tissue it comes from share the target and the medicine relies on the difference in level. HPA TBXT: RNA group enriched (parathyroid gland 2 nTPM, pituitary gland 1 nTPM); no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Sarcomas (soft tissue, bone, GIST)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas TBXT tissue","url":"https://www.proteinatlas.org/ENSG00000164458-TBXT/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Human Protein Atlas TBXT pathology","url":"https://www.proteinatlas.org/ENSG00000164458-TBXT/pathology","note":"patients per staining level per cancer type (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000164458 associations","url":"https://platform.opentargets.org/target/ENSG00000164458/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:11515","ensembl":"ENSG00000164458","uniprot":"O15178","entrez":"6862","firstDescribed":1996,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Edwards Y.H. et al, Genome Res, 1996, \"The human homolog T of the mouse T(Brachyury) gene; gene structure, cDNA sequence, and assignment to chromosome 6q27\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/8963900/","biology":"Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence and activates gene transcription when bound to such a site. Location: Nucleus (UniProt). Locus 6q27 (HGNC).","whereFound":["Chordoma: CIViC evidence names this disease"],"targetClass":"transcription","prevalence":[]},"route":"/targets/tbxt/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"chordoma","kind":"cancer","name":"Chordoma","route":"/cancers/chordoma/"},{"id":"dedifferentiated-chordoma","kind":"cancer","name":"Dedifferentiated chordoma","route":"/cancers/dedifferentiated-chordoma/"},{"id":"poorly-differentiated-chordoma","kind":"cancer","name":"Poorly differentiated chordoma (SMARCB1-deficient)","route":"/cancers/poorly-differentiated-chordoma/"}],"drug":[{"id":"gi-6301","kind":"drug","name":"GI-6301","route":"/drugs/gi-6301/"}]}}