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TBK1 (Serine/threonine-protein kinase TBK1) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Melanoma.
Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerisation and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Selumetinib and AZ909. In OnCo, 1 product record names it (ADU-S100 (MIW815)).
In plain words · TBK1 (Serine/threonine-protein kinase TBK1) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Melanoma.
TBK1 (Serine/threonine-protein kinase TBK1) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Melanoma.
Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents.
No product in this corpus aims at TBK1 yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; the 1 medicine aimed at it (ADU-S100 (MIW815)) act on the wild-type protein, so normal tissue is exposed and the therapeutic window comes from the tumour's faster division or its dependence on the protein. HPA TBK1: RNA low tissue specificity; no normal tissue stained high; highest cancer staining melanoma (6 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Skin cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas TBK1 tissue; Open Targets ENSG00000183735 associations
First described 1999. Earliest sequence paper UniProt cites for the protein: Pomerantz J.L. et al, EMBO J, 1999, "NF-kB activation by a signaling complex containing TRAF2, TANK, and TBK1, a novel IKK-related kinase". Source.
Sources: HGNC HGNC:11584 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UHD2 (protein name, function text, keywords and locations (REST API)); CIViC gene TBK1 (1 evidence items, 0 assertions, 1 variants; diseases: Melanoma (GraphQL API, CC0))
Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerisation and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli. Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, STING1 and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1. Phosphorylated IRF3 dissociates from the adapter proteins, dimerises, and then enters the nucleus to induce expression of interferons. Location: Cytoplasm (UniProt). Locus 12q14.2 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
No normal tissue stained high.
Medium only: carcinoid, colorectal cancer, endometrial cancer, head and neck cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"TBK1" OR ABSTRACT:"TBK1" OR TITLE:"TANK binding kinase 1" OR ABSTRACT:"TANK binding kinase 1" OR TITLE:"Serine/threonine-protein kinase TBK1" OR ABSTRACT:"Serine/threonine-protein kinase TBK1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TBK1, not a curated reading list.
Shares cGAS-STING innate sensing, CIViC.
Shares cGAS-STING innate sensing, Melanoma.