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CXCL10 (C-X-C motif chemokine 10) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Osteosarcoma.
Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects. Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites. Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signalling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganisation.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · CXCL10 (C-X-C motif chemokine 10) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Osteosarcoma.
CXCL10 (C-X-C motif chemokine 10) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Osteosarcoma.
Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects.
No product in this corpus aims at CXCL10 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA CXCL10: RNA tissue enhanced (lymphoid tissue 90 nTPM); blood lineage lineage enriched (monocytes 53 nTPM); no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Sarcomas (soft tissue, bone, GIST)); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas CXCL10 tissue; Open Targets ENSG00000169245 associations
First described 1985. Earliest sequence paper UniProt cites for the protein: Luster A.D. et al, Nature, 1985, "Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins". Source.
Sources: HGNC HGNC:10637 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P02778 (protein name, function text, keywords and locations (REST API)); CIViC gene CXCL10 (1 evidence items, 0 assertions, 1 variants; diseases: Osteosarcoma (GraphQL API, CC0))
Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects. Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites. Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signalling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganisation. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation. Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganisation. Location: Secreted (UniProt). Locus 4q21.1 (HGNC).
RNA: tissue enhanced (lymphoid tissue 90 nTPM), detected in many normal tissues. Blood: lineage enriched (monocytes 53 nTPM).
No normal tissue stained high.
No cancer sample stained medium or high.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"CXCL10" OR ABSTRACT:"CXCL10" OR TITLE:"C-X-C motif chemokine ligand 10" OR ABSTRACT:"C-X-C motif chemokine ligand 10" OR TITLE:"C-X-C motif chemokine 10" OR ABSTRACT:"C-X-C motif chemokine 10" OR TITLE:"IFI10" OR ABSTRACT:"IFI10" OR TITLE:"IP-10" OR ABSTRACT:"IP-10" OR TITLE:"crg-2" OR ABSTRACT:"crg-2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CXCL10, not a curated reading list.
Shares cGAS-STING innate sensing, CIViC.
Shares Osteosarcoma, CIViC.
Shares Osteosarcoma, CIViC.