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SSTR1 (Somatostatin receptor type 1) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Neuroendocrine tumours.
Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.
Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.85, animal model 0.36, genetic association 0.00, clinical 0.90).
In plain words · SSTR1 (Somatostatin receptor type 1) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Neuroendocrine tumours.
SSTR1 (Somatostatin receptor type 1) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Neuroendocrine tumours.
Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.
No product in this corpus aims at SSTR1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA SSTR1: RNA tissue enhanced (brain 9 nTPM, intestine 13 nTPM, stomach 1 21 nTPM); high antibody staining in 4 normal tissues; highest cancer staining colorectal cancer (4 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Neuroendocrine tumours); Open Targets associates it with 1 specific cancer type at or above 0.5 (carcinoid tumor). (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas SSTR1 tissue; Open Targets ENSG00000139874 associations
First described 1992. Earliest sequence paper UniProt cites for the protein: Yamada et al, Proc. Natl. Acad. Sci. U.S.A, 1992, "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney". Source.
Sources: HGNC HGNC:11330 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P30872 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000139874 (association with cancer (MONDO_0004992) 0.58; per-cancer scores at or above 0.5: neuroendocrine neoplasm 0.59 (GraphQL API, CC0))
Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins. Location: Cell membrane (UniProt). Locus 14q21.1 (HGNC).
RNA: tissue enhanced (brain 9 nTPM, intestine 13 nTPM, stomach 1 21 nTPM), detected in some normal tissues.
Medium: Appendix, Cerebral cortex, Colon, Epididymis, Pancreas, Prostate, Rectum, Seminal vesicle.
RNA cancer enhanced: Prostate Adenocarcinoma 7 pTPM.
Medium only: breast cancer, cervical cancer, head and neck cancer, liver cancer.
HPA SSTR1 tissue · HPA SSTR1 pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"SSTR1" OR ABSTRACT:"SSTR1" OR TITLE:"somatostatin receptor 1" OR ABSTRACT:"somatostatin receptor 1" OR TITLE:"Somatostatin receptor type 1" OR ABSTRACT:"Somatostatin receptor type 1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SSTR1, not a curated reading list.