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SPDL1 (spindle apparatus coiled-coil protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Required for the localisation of dynein and dynactin to the mitotic kinetochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation.
Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.73).
In plain words · SPDL1 (spindle apparatus coiled-coil protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
SPDL1 (spindle apparatus coiled-coil protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Required for the localisation of dynein and dynactin to the mitotic kinetochore.
No product in this corpus aims at SPDL1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2000. Earliest sequence paper UniProt cites for the protein: Gu Y.Q. et al, 2000, "Cloning a novel human cDNA having elevated expression when induced with arsenite". Source.
Sources: HGNC HGNC:26010 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96EA4 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000040275 (association with cancer (MONDO_0004992) 0.58; per-cancer scores at or above 0.5: prostate cancer 0.51 (GraphQL API, CC0))
Required for the localisation of dynein and dynactin to the mitotic kinetochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Chromosome, centromere, kinetochore; Nucleus; Cytoplasm, cytoskeleton, spindle pole (UniProt). Locus 5q35.1 (HGNC).
Query for this target: (TITLE:"SPDL1" OR ABSTRACT:"SPDL1" OR TITLE:"spindle apparatus coiled-coil protein 1" OR ABSTRACT:"spindle apparatus coiled-coil protein 1" OR TITLE:"FLJ20364" OR ABSTRACT:"FLJ20364" OR TITLE:"hSpindly" OR ABSTRACT:"hSpindly" OR TITLE:"CCDC99" OR ABSTRACT:"CCDC99") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SPDL1, not a curated reading list.