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SPDL1 (spindle apparatus coiled-coil protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Required for the localisation of dynein and dynactin to the mitotic kinetochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Chromosome, centromere, kinetochore; Nucleus; Cytoplasm, cytoskeleton, spindle pole (UniProt). Locus 5q35.1 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"SPDL1" OR ABSTRACT:"SPDL1" OR TITLE:"spindle apparatus coiled-coil protein 1" OR ABSTRACT:"spindle apparatus coiled-coil protein 1" OR TITLE:"FLJ20364" OR ABSTRACT:"FLJ20364" OR TITLE:"hSpindly" OR ABSTRACT:"hSpindly" OR TITLE:"CCDC99" OR ABSTRACT:"CCDC99") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SPDL1, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/spdl1.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/spdl1.json. Licence CC BY-NC 4.0.