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SOX10 (Transcription factor SOX-10) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Melanoma.
Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Vemurafenib.
In plain words · SOX10 (Transcription factor SOX-10) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Melanoma.
SOX10 (Transcription factor SOX-10) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Melanoma.
Transcription factor that plays a central role in developing and mature glia.
No product in this corpus aims at SOX10 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA group enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA SOX10: RNA group enriched (brain 152 nTPM, salivary gland 105 nTPM); high antibody staining in 3 normal tissues; highest cancer staining glioma (1 of 10 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Skin cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas SOX10 tissue; Open Targets ENSG00000100146 associations
First described 1998. Earliest sequence paper UniProt cites for the protein: Pingault et al, Nat. Genet, 1998, "SOX10 mutations in patients with Waardenburg-Hirschsprung disease". Source.
Sources: HGNC HGNC:11190 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P56693 (protein name, function text, keywords and locations (REST API)); CIViC gene SOX10 (1 evidence items, 0 assertions, 1 variants; diseases: Melanoma (GraphQL API, CC0))
Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3. Transcriptional activator of MBP, via binding to the gene promoter. Location: Cytoplasm; Nucleus; Mitochondrion outer membrane (UniProt). Locus 22q13.1 (HGNC).
RNA: group enriched (brain 152 nTPM, salivary gland 105 nTPM), detected in many normal tissues.
Medium: Cerebellum, Cerebral cortex, Colon, Skin, Soft tissue.
RNA cancer enriched: Skin Cutaneous Melanoma 542 pTPM.
Medium only: melanoma.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"SOX10" OR ABSTRACT:"SOX10" OR TITLE:"SRY-box transcription factor 10" OR ABSTRACT:"SRY-box transcription factor 10" OR TITLE:"Transcription factor SOX-10" OR ABSTRACT:"Transcription factor SOX-10" OR TITLE:"WS4" OR ABSTRACT:"WS4" OR TITLE:"WS2E" OR ABSTRACT:"WS2E" OR TITLE:"SOX-10" OR ABSTRACT:"SOX-10") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SOX10, not a curated reading list.