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SORCS3 (VPS10 domain-containing receptor SorCS3) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Plays an important role in modulating synaptic transmission and plasticity in the hippocampus, probably by affecting the trafficking and localisation ofAMPA-type glutamate receptors in the postsynaptic density.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.80, genetic association 0.63).
In plain words · SORCS3 (VPS10 domain-containing receptor SorCS3) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
SORCS3 (VPS10 domain-containing receptor SorCS3) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Plays an important role in modulating synaptic transmission and plasticity in the hippocampus, probably by affecting the trafficking and localisation ofAMPA-type glutamate receptors in the postsynaptic density.
No product in this corpus aims at SORCS3 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1999. Earliest sequence paper UniProt cites for the protein: Kikuno et al, DNA Res, 1999, "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". Source.
Sources: HGNC HGNC:16699 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UPU3 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000156395 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0))
Plays an important role in modulating synaptic transmission and plasticity in the hippocampus, probably by affecting the trafficking and localisation ofAMPA-type glutamate receptors in the postsynaptic density. Location: Cell membrane; Synaptic cell membrane; Postsynaptic density (UniProt). Locus 10q25.1 (HGNC).
Query for this target: (TITLE:"SORCS3" OR ABSTRACT:"SORCS3" OR TITLE:"sortilin related VPS10 domain containing receptor 3" OR ABSTRACT:"sortilin related VPS10 domain containing receptor 3" OR TITLE:"VPS10 domain-containing receptor SorCS3" OR ABSTRACT:"VPS10 domain-containing receptor SorCS3" OR TITLE:"KIAA1059" OR ABSTRACT:"KIAA1059" OR TITLE:"SORCS" OR ABSTRACT:"SORCS") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SORCS3, not a curated reading list.