{"entity":{"id":"sorcs3","kind":"target","name":"SORCS3","aka":["sortilin related VPS10 domain containing receptor 3","VPS10 domain-containing receptor SorCS3","KIAA1059","SORCS"],"tldr":"SORCS3 (VPS10 domain-containing receptor SorCS3) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Plays an important role in modulating synaptic transmission and plasticity in the hippocampus, probably by affecting the trafficking and localisation ofAMPA-type glutamate receptors in the postsynaptic density.\n\nOpen Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.80, genetic association 0.63).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:16699","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16699"},{"label":"UniProt Q9UPU3","url":"https://www.uniprot.org/uniprotkb/Q9UPU3/entry"},{"label":"NCBI Gene 22986","url":"https://www.ncbi.nlm.nih.gov/gene/22986"},{"label":"Ensembl ENSG00000156395","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000156395"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SORCS3","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:16699","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16699","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9UPU3","url":"https://www.uniprot.org/uniprotkb/Q9UPU3/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000156395","url":"https://platform.opentargets.org/target/ENSG00000156395/associations","note":"association with cancer (MONDO_0004992) 0.51;  (GraphQL API, CC0)"}],"specificitySources":[],"hgnc":"HGNC:16699","ensembl":"ENSG00000156395","uniprot":"Q9UPU3","entrez":"22986","firstDescribed":1999,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Kikuno et al, DNA Res, 1999, \"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/10470851/","biology":"Plays an important role in modulating synaptic transmission and plasticity in the hippocampus, probably by affecting the trafficking and localisation ofAMPA-type glutamate receptors in the postsynaptic density. Location: Cell membrane; Synaptic cell membrane; Postsynaptic density (UniProt). Locus 10q25.1 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/sorcs3/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}