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SNAP25 (Synaptosomal-associated protein 25) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.84, animal model 0.46, genetic association 0.00, clinical 0.78).
In plain words · SNAP25 (Synaptosomal-associated protein 25) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
SNAP25 (Synaptosomal-associated protein 25) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems.
No product in this corpus aims at SNAP25 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA SNAP25: RNA tissue enriched (brain 2,270 nTPM); high antibody staining in 2 normal tissues. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas SNAP25 tissue; Open Targets ENSG00000132639 associations
First described 1994. Earliest sequence paper UniProt cites for the protein: Bark I.C. et al, Gene, 1994, "Human cDNA clones encoding two different isoforms of the nerve terminal protein SNAP-25". Source.
Sources: HGNC HGNC:11132 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P60880 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000132639 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0))
t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. Location: Cytoplasm, perinuclear region; Cell membrane; Synapse, synaptosome; Photoreceptor inner segment (UniProt). Locus 20p12.2 (HGNC).
RNA: tissue enriched (brain 2,270 nTPM), detected in many normal tissues.
RNA cancer enriched: Glioblastoma Multiforme 77 pTPM.
No cancer stained high; medium in stomach cancer.
HPA SNAP25 tissue · HPA SNAP25 pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"SNAP25" OR ABSTRACT:"SNAP25" OR TITLE:"synaptosome associated protein 25" OR ABSTRACT:"synaptosome associated protein 25" OR TITLE:"Synaptosomal-associated protein 25" OR ABSTRACT:"Synaptosomal-associated protein 25" OR TITLE:"SNAP-25" OR ABSTRACT:"SNAP-25" OR TITLE:"RIC-4" OR ABSTRACT:"RIC-4" OR TITLE:"RIC4" OR ABSTRACT:"RIC4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SNAP25, not a curated reading list.