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SLCO1B1 (Solute carrier organic anion transporter family member 1B1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Mediates the Na(+)-independent uptake of organic anions. Shows broad substrate specificity, can transport both organic anions such as bile acid taurocholate (cholyltaurine) and conjugated steroids (dehydroepiandrosterone 3-sulfate, 17-beta-glucuronosyl estradiol, and estrone 3-sulfate), as well as eicosanoids (prostaglandin E2, thromboxane B2, leukotriene C4, and leukotriene E4), and thyroid hormones (T4/L-thyroxine, and T3/3,3',5'-triiodo-L-thyronine). Can take up bilirubin glucuronides from plasma into the liver, contributing to the detoxification-enhancing liver-blood shuttling loop.
CIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Methotrexate.
In plain words · SLCO1B1 (Solute carrier organic anion transporter family member 1B1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
SLCO1B1 (Solute carrier organic anion transporter family member 1B1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Mediates the Na(+)-independent uptake of organic anions.
No product in this corpus aims at SLCO1B1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA SLCO1B1: RNA tissue enriched (liver 502 nTPM); no normal tissue stained high. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas SLCO1B1 tissue; Open Targets ENSG00000134538 associations
First described 1999. Earliest sequence paper UniProt cites for the protein: Abe et al, J. Biol. Chem, 1999, "Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1". Source.
Sources: HGNC HGNC:10959 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9Y6L6 (protein name, function text, keywords and locations (REST API)); CIViC gene SLCO1B1 (2 evidence items, 0 assertions, 2 variants; diseases: Cancer (GraphQL API, CC0))
Mediates the Na(+)-independent uptake of organic anions. Shows broad substrate specificity, can transport both organic anions such as bile acid taurocholate (cholyltaurine) and conjugated steroids (dehydroepiandrosterone 3-sulfate, 17-beta-glucuronosyl estradiol, and estrone 3-sulfate), as well as eicosanoids (prostaglandin E2, thromboxane B2, leukotriene C4, and leukotriene E4), and thyroid hormones (T4/L-thyroxine, and T3/3,3',5'-triiodo-L-thyronine). Can take up bilirubin glucuronides from plasma into the liver, contributing to the detoxification-enhancing liver-blood shuttling loop. Involved in the clearance of endogenous and exogenous substrates from the liver. Transports coproporphyrin I and III, by-products of heme synthesis, and may be involved in their hepatic disposition. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier. Location: Basolateral cell membrane; Basal cell membrane (UniProt). Locus 12p12.1 (HGNC).
RNA: tissue enriched (liver 502 nTPM), detected in single normal tissue.
No normal tissue stained high; medium in Liver.
RNA cancer enriched: Liver Hepatocellular Carcinoma 67 pTPM.
No cancer sample stained medium or high.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"SLCO1B1" OR ABSTRACT:"SLCO1B1" OR TITLE:"solute carrier organic anion transporter family member 1B1" OR ABSTRACT:"solute carrier organic anion transporter family member 1B1" OR TITLE:"Solute carrier organic anion transporter family member 1B1" OR ABSTRACT:"Solute carrier organic anion transporter family member 1B1" OR TITLE:"OATP-C" OR ABSTRACT:"OATP-C" OR TITLE:"LST-1" OR ABSTRACT:"LST-1" OR TITLE:"OATP1B1" OR ABSTRACT:"OATP1B1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SLCO1B1, not a curated reading list.