{"entity":{"id":"slco1b1","kind":"target","name":"SLCO1B1","aka":["solute carrier organic anion transporter family member 1B1","Solute carrier organic anion transporter family member 1B1","OATP-C","LST-1","OATP1B1","SLC21A6"],"tldr":"SLCO1B1 (Solute carrier organic anion transporter family member 1B1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.","summary":"Mediates the Na(+)-independent uptake of organic anions. Shows broad substrate specificity, can transport both organic anions such as bile acid taurocholate (cholyltaurine) and conjugated steroids (dehydroepiandrosterone 3-sulfate, 17-beta-glucuronosyl estradiol, and estrone 3-sulfate), as well as eicosanoids (prostaglandin E2, thromboxane B2, leukotriene C4, and leukotriene E4), and thyroid hormones (T4/L-thyroxine, and T3/3,3',5'-triiodo-L-thyronine). Can take up bilirubin glucuronides from plasma into the liver, contributing to the detoxification-enhancing liver-blood shuttling loop.\n\nCIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Methotrexate.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10959","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10959"},{"label":"UniProt Q9Y6L6","url":"https://www.uniprot.org/uniprotkb/Q9Y6L6/entry"},{"label":"NCBI Gene 10599","url":"https://www.ncbi.nlm.nih.gov/gene/10599"},{"label":"Ensembl ENSG00000134538","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000134538"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SLCO1B1","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:10959","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10959","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9Y6L6","url":"https://www.uniprot.org/uniprotkb/Q9Y6L6/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene SLCO1B1","url":"https://civicdb.org/features/8450","note":"2 evidence items, 0 assertions, 2 variants; diseases: Cancer (GraphQL API, CC0)"}],"distribution":"not-established","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA SLCO1B1: RNA tissue enriched (liver 502 nTPM); no normal tissue stained high. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas SLCO1B1 tissue","url":"https://www.proteinatlas.org/ENSG00000134538-SLCO1B1/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000134538 associations","url":"https://platform.opentargets.org/target/ENSG00000134538/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:10959","ensembl":"ENSG00000134538","uniprot":"Q9Y6L6","entrez":"10599","firstDescribed":1999,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Abe et al, J. Biol. Chem, 1999, \"Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/10358072/","biology":"Mediates the Na(+)-independent uptake of organic anions. Shows broad substrate specificity, can transport both organic anions such as bile acid taurocholate (cholyltaurine) and conjugated steroids (dehydroepiandrosterone 3-sulfate, 17-beta-glucuronosyl estradiol, and estrone 3-sulfate), as well as eicosanoids (prostaglandin E2, thromboxane B2, leukotriene C4, and leukotriene E4), and thyroid hormones (T4/L-thyroxine, and T3/3,3',5'-triiodo-L-thyronine). Can take up bilirubin glucuronides from plasma into the liver, contributing to the detoxification-enhancing liver-blood shuttling loop. Involved in the clearance of endogenous and exogenous substrates from the liver. Transports coproporphyrin I and III, by-products of heme synthesis, and may be involved in their hepatic disposition. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier. Location: Basolateral cell membrane; Basal cell membrane (UniProt). Locus 12p12.1 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/slco1b1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}]}}