Loading
SDC4 (Syndecan-4) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Lung cancer and Non-small-cell lung cancer.
Cell surface proteoglycan which regulates exosome biogenesis in concert with SDCBP and PDCD6IP.
Open Targets scores its association with cancer at 0.72 (direct and indirect evidence; datatypes clinical 0.89, literature 0.94, genetic association 0.00, somatic mutation 0.93, animal model 0.54).
In plain words · SDC4 (Syndecan-4) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Lung cancer and Non-small-cell lung cancer.
SDC4 (Syndecan-4) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Lung cancer and Non-small-cell lung cancer.
Cell surface proteoglycan which regulates exosome biogenesis in concert with SDCBP and PDCD6IP. Location: Membrane; Secreted (UniProt).
No product in this corpus aims at SDC4 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA SDC4: RNA tissue enhanced (liver 384 nTPM); high antibody staining in 25 normal tissues; highest cancer staining ovarian cancer (9 of 10 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lung cancer (all types)); Open Targets associates it with 1 specific cancer type at or above 0.5 (non-small cell lung carcinoma). (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas SDC4 tissue; Open Targets ENSG00000124145 associations
First described 1992. Earliest sequence paper UniProt cites for the protein: David et al, J. Cell Biol, 1992, "Molecular cloning of amphiglycan, a novel integral membrane heparan sulfate proteoglycan expressed by epithelial and fibroblastic cells". Source.
Sources: HGNC HGNC:10661 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P31431 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000124145 (association with cancer (MONDO_0004992) 0.72; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.66, lung cancer 0.67 (GraphQL API, CC0))
Cell surface proteoglycan which regulates exosome biogenesis in concert with SDCBP and PDCD6IP. Location: Membrane; Secreted (UniProt). Locus 20q13.12 (HGNC).
RNA: tissue enhanced (liver 384 nTPM), detected in all normal tissues.
Medium: Adipose tissue, Bone marrow, Cerebellum, Cerebral cortex, Cervix, Epididymis, Esophagus, Heart muscle.
Medium only: carcinoid, lymphoma, melanoma, skin cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"SDC4" OR ABSTRACT:"SDC4" OR TITLE:"syndecan 4" OR ABSTRACT:"syndecan 4" OR TITLE:"Syndecan-4" OR ABSTRACT:"Syndecan-4" OR TITLE:"SYND4" OR ABSTRACT:"SYND4" OR TITLE:"amphiglycan" OR ABSTRACT:"amphiglycan" OR TITLE:"ryudocan" OR ABSTRACT:"ryudocan") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SDC4, not a curated reading list.