{"entity":{"id":"sdc4","kind":"target","name":"SDC4","aka":["syndecan 4","Syndecan-4","SYND4","amphiglycan","ryudocan"],"tldr":"SDC4 (Syndecan-4) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Lung cancer and Non-small-cell lung cancer.","summary":"Cell surface proteoglycan which regulates exosome biogenesis in concert with SDCBP and PDCD6IP.\n\nOpen Targets scores its association with cancer at 0.72 (direct and indirect evidence; datatypes clinical 0.89, literature 0.94, genetic association 0.00, somatic mutation 0.93, animal model 0.54).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10661","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10661"},{"label":"UniProt P31431","url":"https://www.uniprot.org/uniprotkb/P31431/entry"},{"label":"NCBI Gene 6385","url":"https://www.ncbi.nlm.nih.gov/gene/6385"},{"label":"Ensembl ENSG00000124145","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000124145"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["lung-cancer","nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.89. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SDC4","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:10661","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10661","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P31431","url":"https://www.uniprot.org/uniprotkb/P31431/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000124145","url":"https://platform.opentargets.org/target/ENSG00000124145/associations","note":"association with cancer (MONDO_0004992) 0.72; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.66, lung cancer 0.67 (GraphQL API, CC0)"}],"distribution":"one-type","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA SDC4: RNA tissue enhanced (liver 384 nTPM); high antibody staining in 25 normal tissues; highest cancer staining ovarian cancer (9 of 10 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lung cancer (all types)); Open Targets associates it with 1 specific cancer type at or above 0.5 (non-small cell lung carcinoma). (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas SDC4 tissue","url":"https://www.proteinatlas.org/ENSG00000124145-SDC4/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000124145 associations","url":"https://platform.opentargets.org/target/ENSG00000124145/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:10661","ensembl":"ENSG00000124145","uniprot":"P31431","entrez":"6385","firstDescribed":1992,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: David et al, J. Cell Biol, 1992, \"Molecular cloning of amphiglycan, a novel integral membrane heparan sulfate proteoglycan expressed by epithelial and fibroblastic cells\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/1500433/","biology":"Cell surface proteoglycan which regulates exosome biogenesis in concert with SDCBP and PDCD6IP. Location: Membrane; Secreted (UniProt). Locus 20q13.12 (HGNC).","whereFound":["Lung cancer: Open Targets association 0.67 with lung cancer (MONDO_0008903)","Non-small-cell lung cancer: Open Targets association 0.66 with non-small cell lung carcinoma (MONDO_0005233)"],"targetClass":"other","prevalence":[]},"route":"/targets/sdc4/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}]}}