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SCN2A (Sodium channel protein type 2 subunit alpha) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory.
Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.41, genetic association 0.21, clinical 0.86).
In plain words · SCN2A (Sodium channel protein type 2 subunit alpha) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
SCN2A (Sodium channel protein type 2 subunit alpha) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
Mediates the voltage-dependent sodium ion permeability of excitable membranes.
No product in this corpus aims at SCN2A yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA SCN2A: RNA tissue enriched (brain 67 nTPM); high antibody staining in 1 normal tissue. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas SCN2A tissue; Open Targets ENSG00000136531 associations
First described 1991. Earliest sequence paper UniProt cites for the protein: Han et al, Proc. Natl. Acad. Sci. U.S.A, 1991, "Direct amplification of a single dissected chromosomal segment by polymerase chain reaction: a human brain sodium channel gene is on chromosome 2q22-q23". Source.
Sources: HGNC HGNC:10588 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q99250 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000136531 (association with cancer (MONDO_0004992) 0.57; (GraphQL API, CC0))
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory. Location: Cell membrane (UniProt). Locus 2q24.3 (HGNC).
RNA: tissue enriched (brain 67 nTPM), detected in some normal tissues.
Medium: Cerebral cortex, Kidney.
RNA cancer enhanced: Glioblastoma Multiforme 2 pTPM.
No cancer stained high; medium in liver cancer.
HPA SCN2A tissue · HPA SCN2A pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"SCN2A" OR ABSTRACT:"SCN2A" OR TITLE:"sodium voltage-gated channel alpha subunit 2" OR ABSTRACT:"sodium voltage-gated channel alpha subunit 2" OR TITLE:"Sodium channel protein type 2 subunit alpha" OR ABSTRACT:"Sodium channel protein type 2 subunit alpha" OR TITLE:"Nav1.2" OR ABSTRACT:"Nav1.2" OR TITLE:"HBSCII" OR ABSTRACT:"HBSCII" OR TITLE:"HBSCI" OR ABSTRACT:"HBSCI") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SCN2A, not a curated reading list.