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SCN2A (Sodium channel protein type 2 subunit alpha) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory. Location: Cell membrane (UniProt). Locus 2q24.3 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"SCN2A" OR ABSTRACT:"SCN2A" OR TITLE:"sodium voltage-gated channel alpha subunit 2" OR ABSTRACT:"sodium voltage-gated channel alpha subunit 2" OR TITLE:"Sodium channel protein type 2 subunit alpha" OR ABSTRACT:"Sodium channel protein type 2 subunit alpha" OR TITLE:"Nav1.2" OR ABSTRACT:"Nav1.2" OR TITLE:"HBSCII" OR ABSTRACT:"HBSCII" OR TITLE:"HBSCI" OR ABSTRACT:"HBSCI") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SCN2A, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/scn2a.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/scn2a.json. Licence CC BY-NC 4.0.