Loading
SCN11A (Sodium channel protein type 11 subunit alpha) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
Sodium channel mediating the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Involved in membrane depolarisation during action potential in nociceptors which function as key relay stations for the electrical transmission of pain signals from the periphery to the central nervous system.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.20, genetic association 0.00, clinical 0.86).
In plain words · SCN11A (Sodium channel protein type 11 subunit alpha) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
SCN11A (Sodium channel protein type 11 subunit alpha) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
Sodium channel mediating the voltage-dependent sodium ion permeability of excitable membranes.
No product in this corpus aims at SCN11A yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA SCN11A: RNA tissue enhanced (lymphoid tissue 3 nTPM, placenta 2 nTPM, urinary bladder 2 nTPM); no normal tissue stained high; highest cancer staining colorectal cancer (1 of 12 high). Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas SCN11A tissue; Open Targets ENSG00000168356 associations
First described 1999. Earliest sequence paper UniProt cites for the protein: Dib-Hajj S.D. et al, FEBS Lett, 1999, "Two tetrodotoxin-resistant sodium channels in human dorsal root ganglion neurons". Source.
Sources: HGNC HGNC:10583 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UI33 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000168356 (association with cancer (MONDO_0004992) 0.53; (GraphQL API, CC0))
Sodium channel mediating the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Involved in membrane depolarisation during action potential in nociceptors which function as key relay stations for the electrical transmission of pain signals from the periphery to the central nervous system. Also involved in rapid BDNF-evoked neuronal depolarisation. Location: Cell membrane (UniProt). Locus 3p22.2 (HGNC).
RNA: tissue enhanced (lymphoid tissue 3 nTPM, placenta 2 nTPM, urinary bladder 2 nTPM), detected in some normal tissues.
No normal tissue stained high.
Medium only: carcinoid, ovarian cancer, pancreatic cancer, skin cancer.
HPA SCN11A tissue · HPA SCN11A pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"SCN11A" OR ABSTRACT:"SCN11A" OR TITLE:"sodium voltage-gated channel alpha subunit 11" OR ABSTRACT:"sodium voltage-gated channel alpha subunit 11" OR TITLE:"Sodium channel protein type 11 subunit alpha" OR ABSTRACT:"Sodium channel protein type 11 subunit alpha" OR TITLE:"Nav1.9" OR ABSTRACT:"Nav1.9" OR TITLE:"NaN" OR ABSTRACT:"NaN" OR TITLE:"SNS-2" OR ABSTRACT:"SNS-2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SCN11A, not a curated reading list.