{"entity":{"id":"scn11a","kind":"target","name":"SCN11A","aka":["sodium voltage-gated channel alpha subunit 11","Sodium channel protein type 11 subunit alpha","Nav1.9","NaN","SNS-2","SCN12A"],"tldr":"SCN11A (Sodium channel protein type 11 subunit alpha) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.","summary":"Sodium channel mediating the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Involved in membrane depolarisation during action potential in nociceptors which function as key relay stations for the electrical transmission of pain signals from the periphery to the central nervous system.\n\nOpen Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.20, genetic association 0.00, clinical 0.86).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10583","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10583"},{"label":"UniProt Q9UI33","url":"https://www.uniprot.org/uniprotkb/Q9UI33/entry"},{"label":"NCBI Gene 11280","url":"https://www.ncbi.nlm.nih.gov/gene/11280"},{"label":"Ensembl ENSG00000168356","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000168356"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.86. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SCN11A","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:10583","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10583","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9UI33","url":"https://www.uniprot.org/uniprotkb/Q9UI33/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000168356","url":"https://platform.opentargets.org/target/ENSG00000168356/associations","note":"association with cancer (MONDO_0004992) 0.53;  (GraphQL API, CC0)"}],"distribution":"not-established","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA SCN11A: RNA tissue enhanced (lymphoid tissue 3 nTPM, placenta 2 nTPM, urinary bladder 2 nTPM); no normal tissue stained high; highest cancer staining colorectal cancer (1 of 12 high). Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas SCN11A tissue","url":"https://www.proteinatlas.org/ENSG00000168356-SCN11A/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000168356 associations","url":"https://platform.opentargets.org/target/ENSG00000168356/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:10583","ensembl":"ENSG00000168356","uniprot":"Q9UI33","entrez":"11280","firstDescribed":1999,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Dib-Hajj S.D. et al, FEBS Lett, 1999, \"Two tetrodotoxin-resistant sodium channels in human dorsal root ganglion neurons\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/10580103/","biology":"Sodium channel mediating the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Involved in membrane depolarisation during action potential in nociceptors which function as key relay stations for the electrical transmission of pain signals from the periphery to the central nervous system. Also involved in rapid BDNF-evoked neuronal depolarisation. Location: Cell membrane (UniProt). Locus 3p22.2 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/scn11a/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}