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S1PR1 (Sphingosine 1-phosphate receptor 1) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Mantle cell lymphoma.
G protein-coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signalling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganisation of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · S1PR1 (Sphingosine 1-phosphate receptor 1) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Mantle cell lymphoma.
S1PR1 (Sphingosine 1-phosphate receptor 1) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Mantle cell lymphoma.
G protein-coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signalling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases.
No product in this corpus aims at S1PR1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA S1PR1: RNA low tissue specificity; high antibody staining in 13 normal tissues; highest cancer staining thyroid cancer (3 of 4 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas S1PR1 tissue; Open Targets ENSG00000170989 associations
First described 1990. Earliest sequence paper UniProt cites for the protein: Hla et al, J. Biol. Chem, 1990, "An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors". Source.
Sources: HGNC HGNC:3165 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P21453 (protein name, function text, keywords and locations (REST API)); CIViC gene S1PR1 (1 evidence items, 0 assertions, 1 variants; diseases: Mantle Cell Lymphoma (GraphQL API, CC0))
G protein-coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signalling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganisation of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Location: Cell membrane; Endosome; Membrane raft (UniProt). Locus 1p21.2 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Bone marrow, Breast, Duodenum, Endometrium, Epididymis, Esophagus, Fallopian tube, Gallbladder.
RNA cancer enhanced: Kidney Renal Clear Cell Carcinoma 59 pTPM.
Medium only: carcinoid, cervical cancer, head and neck cancer, lung cancer.
HPA S1PR1 tissue · HPA S1PR1 pathology · HPA protein class: CD markers, FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"S1PR1" OR ABSTRACT:"S1PR1" OR TITLE:"sphingosine-1-phosphate receptor 1" OR ABSTRACT:"sphingosine-1-phosphate receptor 1" OR TITLE:"Sphingosine 1-phosphate receptor 1" OR ABSTRACT:"Sphingosine 1-phosphate receptor 1" OR TITLE:"edg-1" OR ABSTRACT:"edg-1" OR TITLE:"D1S3362" OR ABSTRACT:"D1S3362" OR TITLE:"CD363" OR ABSTRACT:"CD363") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about S1PR1, not a curated reading list.