{"entity":{"id":"s1pr1","kind":"target","name":"S1PR1","aka":["sphingosine-1-phosphate receptor 1","Sphingosine 1-phosphate receptor 1","edg-1","D1S3362","CD363","EDG1"],"tldr":"S1PR1 (Sphingosine 1-phosphate receptor 1) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Mantle cell lymphoma.","summary":"G protein-coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signalling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganisation of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3165","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3165"},{"label":"UniProt P21453","url":"https://www.uniprot.org/uniprotkb/P21453/entry"},{"label":"NCBI Gene 1901","url":"https://www.ncbi.nlm.nih.gov/gene/1901"},{"label":"Ensembl ENSG00000170989","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000170989"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["mantle-cell-lymphoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"S1PR1","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:3165","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3165","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P21453","url":"https://www.uniprot.org/uniprotkb/P21453/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene S1PR1","url":"https://civicdb.org/features/1603","note":"1 evidence items, 0 assertions, 1 variants; diseases: Mantle Cell Lymphoma (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"one-type","specificityNote":"Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA S1PR1: RNA low tissue specificity; high antibody staining in 13 normal tissues; highest cancer staining thyroid cancer (3 of 4 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas S1PR1 tissue","url":"https://www.proteinatlas.org/ENSG00000170989-S1PR1/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000170989 associations","url":"https://platform.opentargets.org/target/ENSG00000170989/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:3165","ensembl":"ENSG00000170989","uniprot":"P21453","entrez":"1901","firstDescribed":1990,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Hla et al, J. Biol. Chem, 1990, \"An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/2160972/","biology":"G protein-coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signalling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganisation of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Location: Cell membrane; Endosome; Membrane raft (UniProt). Locus 1p21.2 (HGNC).","whereFound":["Mantle cell lymphoma: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/s1pr1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"mantle-cell-lymphoma","kind":"cancer","name":"Mantle cell lymphoma","route":"/cancers/mantle-cell-lymphoma/"}]}}