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S100B (S100 calcium binding protein B) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Small zinc- and- and calcium-binding protein that is highly expressed in astrocytes and constitutes one of the most abundant soluble proteins in brain. Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonise the binding of both divalent cations, especially affecting high-affinity calcium-binding sites.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · S100B (S100 calcium binding protein B) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
S100B (S100 calcium binding protein B) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Small zinc- and- and calcium-binding protein that is highly expressed in astrocytes and constitutes one of the most abundant soluble proteins in brain.
No product in this corpus aims at S100B yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA S100B: RNA tissue enriched (brain 4,757 nTPM); blood lineage lineage enriched (T-cells 362 nTPM); high antibody staining in 8 normal tissues; highest cancer staining breast cancer (6 of 12 high). Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas S100B tissue; Open Targets ENSG00000160307 associations
First described 1985. Earliest sequence paper UniProt cites for the protein: Jensen et al, J. Neurochem, 1985, "Characterization of human brain S100 protein fraction: amino acid sequence of S100 beta". Source.
Sources: HGNC HGNC:10500 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P04271 (protein name, function text, keywords and locations (REST API)); CIViC gene S100B (1 evidence items, 0 assertions, 1 variants; diseases: Lipofibromatosis-like Neural Tumour (GraphQL API, CC0))
Small zinc- and- and calcium-binding protein that is highly expressed in astrocytes and constitutes one of the most abundant soluble proteins in brain. Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonise the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Acts as a neurotrophic factor that promotes astrocytosis and axonal proliferation. Involved in innervation of thermogenic adipose tissue by acting as an adipocyte-derived neurotrophic factor that promotes sympathetic innervation of adipose tissue. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Location: Cytoplasm; Nucleus; Secreted (UniProt). Locus 21q22.3 (HGNC).
RNA: tissue enriched (brain 4,757 nTPM), detected in many normal tissues. Blood: lineage enriched (T-cells 362 nTPM).
Medium: Adipose tissue, Kidney, Placenta.
RNA group enriched: Glioblastoma Multiforme 1,025 pTPM, Skin Cutaneous Melanoma 1,224 pTPM.
Medium only: carcinoid, cervical cancer, colorectal cancer, endometrial cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"S100B" OR ABSTRACT:"S100B" OR TITLE:"S100 calcium binding protein B" OR ABSTRACT:"S100 calcium binding protein B" OR TITLE:"S100beta" OR ABSTRACT:"S100beta") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about S100B, not a curated reading list.