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RPS6 (Small ribosomal subunit protein eS6) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer.
Component of the 40S small ribosomal subunit. Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Everolimus.
In plain words · RPS6 (Small ribosomal subunit protein eS6) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer.
RPS6 (Small ribosomal subunit protein eS6) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer.
Component of the 40S small ribosomal subunit. Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.
No product in this corpus aims at RPS6 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA lists RPS6 among essential proteins and finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA RPS6: RNA low tissue specificity; high antibody staining in 23 normal tissues; highest cancer staining head and neck cancer (3 of 4 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Gastric & gastro-oesophageal junction cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas RPS6 tissue; Open Targets ENSG00000137154 associations
First described 1988. Earliest sequence paper UniProt cites for the protein: Lott J.B. et al, Gene, 1988, "Isolation and characterization of cloned cDNAs that code for human ribosomal protein S6". Source.
Sources: HGNC HGNC:10429 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P62753 (protein name, function text, keywords and locations (REST API)); CIViC gene RPS6 (1 evidence items, 0 assertions, 1 variants; diseases: Gastric Adenocarcinoma (GraphQL API, CC0))
Component of the 40S small ribosomal subunit. Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Location: Cytoplasm; Nucleus, nucleolus (UniProt). Locus 9p22.1 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Adipose tissue, Adrenal gland, Bronchus, Colon, Endometrium, Epididymis, Fallopian tube, Hippocampus.
Medium only: breast cancer, carcinoid, cervical cancer, glioma.
HPA RPS6 tissue · HPA RPS6 pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"RPS6" OR ABSTRACT:"RPS6" OR TITLE:"ribosomal protein S6" OR ABSTRACT:"ribosomal protein S6" OR TITLE:"Small ribosomal subunit protein eS6" OR ABSTRACT:"Small ribosomal subunit protein eS6" OR TITLE:"S6" OR ABSTRACT:"S6" OR TITLE:"eS6" OR ABSTRACT:"eS6") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RPS6, not a curated reading list.