{"entity":{"id":"rps6","kind":"target","name":"RPS6","aka":["ribosomal protein S6","Small ribosomal subunit protein eS6","S6","eS6"],"tldr":"RPS6 (Small ribosomal subunit protein eS6) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer.","summary":"Component of the 40S small ribosomal subunit. Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Everolimus.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10429","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10429"},{"label":"UniProt P62753","url":"https://www.uniprot.org/uniprotkb/P62753/entry"},{"label":"NCBI Gene 6194","url":"https://www.ncbi.nlm.nih.gov/gene/6194"},{"label":"Ensembl ENSG00000137154","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000137154"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["gastric"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"RPS6","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:10429","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10429","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P62753","url":"https://www.uniprot.org/uniprotkb/P62753/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene RPS6","url":"https://civicdb.org/features/5013","note":"1 evidence items, 0 assertions, 1 variants; diseases: Gastric Adenocarcinoma (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"one-type","specificityNote":"Broadly expressed or essential: HPA lists RPS6 among essential proteins and finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA RPS6: RNA low tissue specificity; high antibody staining in 23 normal tissues; highest cancer staining head and neck cancer (3 of 4 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Gastric & gastro-oesophageal junction cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas RPS6 tissue","url":"https://www.proteinatlas.org/ENSG00000137154-RPS6/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000137154 associations","url":"https://platform.opentargets.org/target/ENSG00000137154/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:10429","ensembl":"ENSG00000137154","uniprot":"P62753","entrez":"6194","firstDescribed":1988,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Lott J.B. et al, Gene, 1988, \"Isolation and characterization of cloned cDNAs that code for human ribosomal protein S6\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/2840355/","biology":"Component of the 40S small ribosomal subunit. Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Location: Cytoplasm; Nucleus, nucleolus (UniProt). Locus 9p22.1 (HGNC).","whereFound":["Gastric & gastro-oesophageal junction cancer: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/rps6/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"}]}}