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RPS26 (Small ribosomal subunit protein eS26) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.13, genetic association 0.27, genetic literature 0.76, clinical 0.11).
In plain words · RPS26 (Small ribosomal subunit protein eS26) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
RPS26 (Small ribosomal subunit protein eS26) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
No product in this corpus aims at RPS26 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA RPS26: RNA low tissue specificity; no normal tissue stained high. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 1 specific cancer type at or above 0.5 (Diamond-Blackfan anemia). (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas RPS26 tissue; Open Targets ENSG00000197728 associations
First described 1993. Earliest sequence paper UniProt cites for the protein: Vincent et al, Nucleic Acids Res, 1993, "S26 ribosomal protein RNA: an invariant control for gene regulation experiments in eucaryotic cells and tissues". Source.
Sources: HGNC HGNC:10414 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P62854 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000197728 (association with cancer (MONDO_0004992) 0.52; (GraphQL API, CC0))
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Location: Cytoplasm, cytosol; Cytoplasm; Rough endoplasmic reticulum (UniProt). Locus 12q13.2 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
No normal tissue stained high.
No cancer stained high; medium in colorectal cancer, endometrial cancer, liver cancer, ovarian cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"RPS26" OR ABSTRACT:"RPS26" OR TITLE:"ribosomal protein S26" OR ABSTRACT:"ribosomal protein S26" OR TITLE:"Small ribosomal subunit protein eS26" OR ABSTRACT:"Small ribosomal subunit protein eS26" OR TITLE:"S26" OR ABSTRACT:"S26" OR TITLE:"eS26" OR ABSTRACT:"eS26") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RPS26, not a curated reading list.