{"entity":{"id":"rps26","kind":"target","name":"RPS26","aka":["ribosomal protein S26","Small ribosomal subunit protein eS26","S26","eS26"],"tldr":"RPS26 (Small ribosomal subunit protein eS26) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.","summary":"Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.\n\nOpen Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.13, genetic association 0.27, genetic literature 0.76, clinical 0.11).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10414","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10414"},{"label":"UniProt P62854","url":"https://www.uniprot.org/uniprotkb/P62854/entry"},{"label":"NCBI Gene 6231","url":"https://www.ncbi.nlm.nih.gov/gene/6231"},{"label":"Ensembl ENSG00000197728","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000197728"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.11. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"RPS26","role":["drug-target"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:10414","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10414","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P62854","url":"https://www.uniprot.org/uniprotkb/P62854/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000197728","url":"https://platform.opentargets.org/target/ENSG00000197728/associations","note":"association with cancer (MONDO_0004992) 0.52;  (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"one-type","specificityNote":"Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA RPS26: RNA low tissue specificity; no normal tissue stained high. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 1 specific cancer type at or above 0.5 (Diamond-Blackfan anemia). (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas RPS26 tissue","url":"https://www.proteinatlas.org/ENSG00000197728-RPS26/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000197728 associations","url":"https://platform.opentargets.org/target/ENSG00000197728/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:10414","ensembl":"ENSG00000197728","uniprot":"P62854","entrez":"6231","firstDescribed":1993,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Vincent et al, Nucleic Acids Res, 1993, \"S26 ribosomal protein RNA: an invariant control for gene regulation experiments in eucaryotic cells and tissues\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/8464749/","biology":"Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Location: Cytoplasm, cytosol; Cytoplasm; Rough endoplasmic reticulum (UniProt). Locus 12q13.2 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/rps26/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}