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RPS24 (Small ribosomal subunit protein eS24) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for processing of pre-rRNA and maturation of 40S ribosomal subunits.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.86, genetic association 0.29, clinical 0.11, genetic literature 0.76).
In plain words · RPS24 (Small ribosomal subunit protein eS24) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
RPS24 (Small ribosomal subunit protein eS24) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
No product in this corpus aims at RPS24 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA lists RPS24 among essential proteins and finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA RPS24: RNA low tissue specificity; no normal tissue stained high. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 1 specific cancer type at or above 0.5 (Diamond-Blackfan anemia). (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas RPS24 tissue; Open Targets ENSG00000138326 associations
First described 1990. Earliest sequence paper UniProt cites for the protein: Brown S.J. et al, Gene, 1990, "A cDNA encoding human ribosomal protein S24". Source.
Sources: HGNC HGNC:10411 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P62847 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000138326 (association with cancer (MONDO_0004992) 0.53; (GraphQL API, CC0))
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for processing of pre-rRNA and maturation of 40S ribosomal subunits. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Location: Cytoplasm; Nucleus, nucleolus (UniProt). Locus 10q22.3 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
No normal tissue stained high; medium in Breast, Cerebellum, Duodenum, Endometrium, Pancreas, Skin and more.
No cancer stained high; medium in breast cancer, colorectal cancer, lung cancer, skin cancer.
HPA RPS24 tissue · HPA RPS24 pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"RPS24" OR ABSTRACT:"RPS24" OR TITLE:"ribosomal protein S24" OR ABSTRACT:"ribosomal protein S24" OR TITLE:"Small ribosomal subunit protein eS24" OR ABSTRACT:"Small ribosomal subunit protein eS24" OR TITLE:"S24" OR ABSTRACT:"S24" OR TITLE:"eS24" OR ABSTRACT:"eS24") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RPS24, not a curated reading list.