{"entity":{"id":"rps24","kind":"target","name":"RPS24","aka":["ribosomal protein S24","Small ribosomal subunit protein eS24","S24","eS24"],"tldr":"RPS24 (Small ribosomal subunit protein eS24) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.","summary":"Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for processing of pre-rRNA and maturation of 40S ribosomal subunits.\n\nOpen Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.86, genetic association 0.29, clinical 0.11, genetic literature 0.76).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10411","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10411"},{"label":"UniProt P62847","url":"https://www.uniprot.org/uniprotkb/P62847/entry"},{"label":"NCBI Gene 6229","url":"https://www.ncbi.nlm.nih.gov/gene/6229"},{"label":"Ensembl ENSG00000138326","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000138326"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.11. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"RPS24","role":["drug-target"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:10411","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10411","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P62847","url":"https://www.uniprot.org/uniprotkb/P62847/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000138326","url":"https://platform.opentargets.org/target/ENSG00000138326/associations","note":"association with cancer (MONDO_0004992) 0.53;  (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"one-type","specificityNote":"Broadly expressed or essential: HPA lists RPS24 among essential proteins and finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA RPS24: RNA low tissue specificity; no normal tissue stained high. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 1 specific cancer type at or above 0.5 (Diamond-Blackfan anemia). (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas RPS24 tissue","url":"https://www.proteinatlas.org/ENSG00000138326-RPS24/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000138326 associations","url":"https://platform.opentargets.org/target/ENSG00000138326/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:10411","ensembl":"ENSG00000138326","uniprot":"P62847","entrez":"6229","firstDescribed":1990,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Brown S.J. et al, Gene, 1990, \"A cDNA encoding human ribosomal protein S24\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/2210388/","biology":"Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for processing of pre-rRNA and maturation of 40S ribosomal subunits. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Location: Cytoplasm; Nucleus, nucleolus (UniProt). Locus 10q22.3 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/rps24/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}