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RPS19 (Small ribosomal subunit protein eS19) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for pre-rRNA processing and maturation of 40S ribosomal subunits.
Open Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes clinical 0.11, genetic literature 0.76, literature 0.64, genetic association 0.18, animal model 0.43).
In plain words · RPS19 (Small ribosomal subunit protein eS19) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
RPS19 (Small ribosomal subunit protein eS19) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
No product in this corpus aims at RPS19 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA lists RPS19 among essential proteins and finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA RPS19: RNA low tissue specificity; no normal tissue stained high. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 1 specific cancer type at or above 0.5 (Diamond-Blackfan anemia). (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas RPS19 tissue; Open Targets ENSG00000105372 associations
First described 1992. Earliest sequence paper UniProt cites for the protein: Kondoh et al, Cancer Res, 1992, "Differential expression of S19 ribosomal protein, laminin-binding protein, and human lymphocyte antigen class I messenger RNAs associated with colon carcinoma progression and differentiation". Source.
Sources: HGNC HGNC:10402 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P39019 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000105372 (association with cancer (MONDO_0004992) 0.50; (GraphQL API, CC0))
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for pre-rRNA processing and maturation of 40S ribosomal subunits. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Location: Cytoplasm; Nucleus, nucleolus (UniProt). Locus 19q13.2 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
No normal tissue stained high.
No cancer sample stained medium or high.
HPA RPS19 tissue · HPA RPS19 pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"RPS19" OR ABSTRACT:"RPS19" OR TITLE:"ribosomal protein S19" OR ABSTRACT:"ribosomal protein S19" OR TITLE:"Small ribosomal subunit protein eS19" OR ABSTRACT:"Small ribosomal subunit protein eS19" OR TITLE:"S19" OR ABSTRACT:"S19" OR TITLE:"eS19" OR ABSTRACT:"eS19" OR TITLE:"LOH19CR1" OR ABSTRACT:"LOH19CR1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RPS19, not a curated reading list.