{"entity":{"id":"rps19","kind":"target","name":"RPS19","aka":["ribosomal protein S19","Small ribosomal subunit protein eS19","S19","eS19","LOH19CR1"],"tldr":"RPS19 (Small ribosomal subunit protein eS19) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.","summary":"Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for pre-rRNA processing and maturation of 40S ribosomal subunits.\n\nOpen Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes clinical 0.11, genetic literature 0.76, literature 0.64, genetic association 0.18, animal model 0.43).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10402","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10402"},{"label":"UniProt P39019","url":"https://www.uniprot.org/uniprotkb/P39019/entry"},{"label":"NCBI Gene 6223","url":"https://www.ncbi.nlm.nih.gov/gene/6223"},{"label":"Ensembl ENSG00000105372","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000105372"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.11. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"RPS19","role":["drug-target"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:10402","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10402","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P39019","url":"https://www.uniprot.org/uniprotkb/P39019/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000105372","url":"https://platform.opentargets.org/target/ENSG00000105372/associations","note":"association with cancer (MONDO_0004992) 0.50;  (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"one-type","specificityNote":"Broadly expressed or essential: HPA lists RPS19 among essential proteins and finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA RPS19: RNA low tissue specificity; no normal tissue stained high. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 1 specific cancer type at or above 0.5 (Diamond-Blackfan anemia). (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas RPS19 tissue","url":"https://www.proteinatlas.org/ENSG00000105372-RPS19/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000105372 associations","url":"https://platform.opentargets.org/target/ENSG00000105372/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:10402","ensembl":"ENSG00000105372","uniprot":"P39019","entrez":"6223","firstDescribed":1992,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Kondoh et al, Cancer Res, 1992, \"Differential expression of S19 ribosomal protein, laminin-binding protein, and human lymphocyte antigen class I messenger RNAs associated with colon carcinoma progression and differentiation\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/1339304/","biology":"Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for pre-rRNA processing and maturation of 40S ribosomal subunits. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Location: Cytoplasm; Nucleus, nucleolus (UniProt). Locus 19q13.2 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/rps19/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}