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RPL22 (Large ribosomal subunit protein eL22) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a drug target and a tumour suppressor, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma, Colorectal cancer and Gastric & gastro-oesophageal junction cancer.
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.90, genetic association 0.00, somatic mutation 0.83, clinical 0.11). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Hepatocellular Carcinoma.
In plain words · RPL22 (Large ribosomal subunit protein eL22) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a drug target and a tumour suppressor, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma, Colorectal cancer and Gastric & gastro-oesophageal junction cancer.
RPL22 (Large ribosomal subunit protein eL22) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a drug target and a tumour suppressor, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma, Colorectal cancer and Gastric & gastro-oesophageal junction cancer.
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
No product in this corpus aims at RPL22 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
Tumour-specific alteration: the catalogues call it a tumour suppressor (IntOGen finds it knocked out more often than chance); what a medicine would aim at or exploit is the altered form or its loss, absent from normal cells; no corpus medicine is aimed at it yet. HPA RPL22: RNA low tissue specificity; no normal tissue stained high. Distribution: 3 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Hepatocellular carcinoma, Colorectal cancer, Gastric & gastro-oesophageal junction cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 6 of scripts/fetch-target-specificity.ts.)
Sources: UniProt P35268; IntOGen RPL22; Human Protein Atlas RPL22 tissue; Open Targets ENSG00000116251 associations
First described 1991. Earliest sequence paper UniProt cites for the protein: Toczyski D.P.W. et al, EMBO J, 1991, "EAP, a highly conserved cellular protein associated with Epstein-Barr virus small RNAs (EBERs)". Source.
Sources: HGNC HGNC:10315 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P35268 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000116251 (association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: colorectal cancer 0.53, gastric cancer 0.53 (GraphQL API, CC0)); IntOGen RPL22 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Location: Cytoplasm (UniProt). Locus 1p36.31 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
No normal tissue stained high.
No cancer sample stained medium or high.
HPA RPL22 tissue · HPA RPL22 pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"RPL22" OR ABSTRACT:"RPL22" OR TITLE:"ribosomal protein L22" OR ABSTRACT:"ribosomal protein L22" OR TITLE:"Large ribosomal subunit protein eL22" OR ABSTRACT:"Large ribosomal subunit protein eL22" OR TITLE:"L22" OR ABSTRACT:"L22" OR TITLE:"eL22" OR ABSTRACT:"eL22") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RPL22, not a curated reading list.