{"entity":{"id":"rpl22","kind":"target","name":"RPL22","aka":["ribosomal protein L22","Large ribosomal subunit protein eL22","L22","eL22"],"tldr":"RPL22 (Large ribosomal subunit protein eL22) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a drug target and a tumour suppressor, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma, Colorectal cancer and Gastric & gastro-oesophageal junction cancer.","summary":"Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.\n\nOpen Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.90, genetic association 0.00, somatic mutation 0.83, clinical 0.11). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Hepatocellular Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10315","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10315"},{"label":"UniProt P35268","url":"https://www.uniprot.org/uniprotkb/P35268/entry"},{"label":"NCBI Gene 6146","url":"https://www.ncbi.nlm.nih.gov/gene/6146"},{"label":"Ensembl ENSG00000116251","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000116251"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["hcc","colorectal","gastric"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.11; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"RPL22","role":["drug-target","tumour-suppressor"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:10315","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10315","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P35268","url":"https://www.uniprot.org/uniprotkb/P35268/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000116251","url":"https://platform.opentargets.org/target/ENSG00000116251/associations","note":"association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: colorectal cancer 0.53, gastric cancer 0.53 (GraphQL API, CC0)"},{"label":"IntOGen RPL22","url":"https://www.intogen.org/search?gene=RPL22","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"specificity":"tumour-specific","distribution":"few-types","specificityNote":"Tumour-specific alteration: the catalogues call it a tumour suppressor (IntOGen finds it knocked out more often than chance); what a medicine would aim at or exploit is the altered form or its loss, absent from normal cells; no corpus medicine is aimed at it yet. HPA RPL22: RNA low tissue specificity; no normal tissue stained high. Distribution: 3 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Hepatocellular carcinoma, Colorectal cancer, Gastric & gastro-oesophageal junction cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 6 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"UniProt P35268","url":"https://www.uniprot.org/uniprotkb/P35268/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen RPL22","url":"https://www.intogen.org/search?gene=RPL22","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"},{"label":"Human Protein Atlas RPL22 tissue","url":"https://www.proteinatlas.org/ENSG00000116251-RPL22/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000116251 associations","url":"https://platform.opentargets.org/target/ENSG00000116251/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:10315","ensembl":"ENSG00000116251","uniprot":"P35268","entrez":"6146","firstDescribed":1991,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Toczyski D.P.W. et al, EMBO J, 1991, \"EAP, a highly conserved cellular protein associated with Epstein-Barr virus small RNAs (EBERs)\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/1846807/","biology":"Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Location: Cytoplasm (UniProt). Locus 1p36.31 (HGNC).","whereFound":["Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC)","Colorectal cancer: Open Targets association 0.53 with colorectal cancer (MONDO_0005575)","Gastric & gastro-oesophageal junction cancer: Open Targets association 0.53 with gastric cancer (MONDO_0001056)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/rpl22/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"}]}}