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RMI2 (RecQ-mediated genome instability protein 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Non-Hodgkin lymphoma, Breast cancer, Lung cancer and 1 more.
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localisation, and function of BLM, TOP3A, and complexes containing BLM.
Open Targets scores its association with cancer at 0.76 (direct and indirect evidence; datatypes literature 0.89, affected pathway 0.87, genetic association 0.41, somatic mutation 0.97).
In plain words · RMI2 (RecQ-mediated genome instability protein 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Non-Hodgkin lymphoma, Breast cancer, Lung cancer and 1 more.
RMI2 (RecQ-mediated genome instability protein 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Non-Hodgkin lymphoma, Breast cancer, Lung cancer and 1 more.
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover.
No product in this corpus aims at RMI2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2004. Earliest sequence paper UniProt cites for the protein: Ota et al, Nat. Genet, 2004, "Complete sequencing and characterization of 21,243 full-length human cDNAs". Source.
Sources: HGNC HGNC:28349 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96E14 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000175643 (association with cancer (MONDO_0004992) 0.76; per-cancer scores at or above 0.5: diffuse large B-cell lymphoma 0.57, non-Hodgkin lymphoma 0.61, breast cancer 0.54, lung cancer 0.50 (GraphQL API, CC0))
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localisation, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM. Location: Nucleus (UniProt). Locus 16p13.13 (HGNC).
Query for this target: (TITLE:"RMI2" OR ABSTRACT:"RMI2" OR TITLE:"RecQ mediated genome instability 2" OR ABSTRACT:"RecQ mediated genome instability 2" OR TITLE:"RecQ-mediated genome instability protein 2" OR ABSTRACT:"RecQ-mediated genome instability protein 2" OR TITLE:"MGC24665" OR ABSTRACT:"MGC24665" OR TITLE:"BLAP18" OR ABSTRACT:"BLAP18" OR TITLE:"C16orf75" OR ABSTRACT:"C16orf75") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RMI2, not a curated reading list.