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RMI2 (RecQ-mediated genome instability protein 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Non-Hodgkin lymphoma, Breast cancer, Lung cancer and 1 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localisation, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM. Location: Nucleus (UniProt). Locus 16p13.13 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"RMI2" OR ABSTRACT:"RMI2" OR TITLE:"RecQ mediated genome instability 2" OR ABSTRACT:"RecQ mediated genome instability 2" OR TITLE:"RecQ-mediated genome instability protein 2" OR ABSTRACT:"RecQ-mediated genome instability protein 2" OR TITLE:"MGC24665" OR ABSTRACT:"MGC24665" OR TITLE:"BLAP18" OR ABSTRACT:"BLAP18" OR TITLE:"C16orf75" OR ABSTRACT:"C16orf75") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RMI2, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/rmi2.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/rmi2.json. Licence CC BY-NC 4.0.