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RIT1 (GTP-binding protein Rit1) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Endometrial cancer and Non-small-cell lung cancer.
Plays a crucial role in coupling nerve growth factor (NGF) stimulation to the activation of both EPHB2 and MAPK14 signalling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signalling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation. Recognised by LZTR1, which mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex.
CIViC holds 14 clinical evidence items and 0 assertions across 8 variants, naming Selumetinib and Pictilisib.
In plain words · RIT1 (GTP-binding protein Rit1) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Endometrial cancer and Non-small-cell lung cancer.
RIT1 (GTP-binding protein Rit1) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Endometrial cancer and Non-small-cell lung cancer.
Plays a crucial role in coupling nerve growth factor (NGF) stimulation to the activation of both EPHB2 and MAPK14 signalling pathways and in NGF-dependent neuronal differentiation.
No product in this corpus aims at RIT1 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA RIT1: RNA low tissue specificity; high antibody staining in 10 normal tissues; highest cancer staining colorectal cancer (6 of 12 high). Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Endometrial cancer, Lung cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas RIT1 tissue; Open Targets ENSG00000143622 associations
First described 1996. Earliest sequence paper UniProt cites for the protein: Lee C.H.J. et al, J. Neurosci, 1996, "Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins". Source.
Sources: HGNC HGNC:10023 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q92963 (protein name, function text, keywords and locations (REST API)); CIViC gene RIT1 (14 evidence items, 0 assertions, 8 variants; diseases: Lung Adenocarcinoma, Endometrial Cancer (GraphQL API, CC0))
Plays a crucial role in coupling nerve growth factor (NGF) stimulation to the activation of both EPHB2 and MAPK14 signalling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signalling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation. Recognised by LZTR1, which mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. Location: Cell membrane (UniProt). Locus 1q22 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Adrenal gland, Appendix, Bone marrow, Breast, Cerebral cortex, Cervix, Colon, Endometrium.
Medium only: breast cancer, glioma, head and neck cancer, lymphoma.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"RIT1" OR ABSTRACT:"RIT1" OR TITLE:"Ras like without CAAX 1" OR ABSTRACT:"Ras like without CAAX 1" OR TITLE:"GTP-binding protein Rit1" OR ABSTRACT:"GTP-binding protein Rit1" OR TITLE:"ROC1" OR ABSTRACT:"ROC1" OR TITLE:"MGC125864" OR ABSTRACT:"MGC125864" OR TITLE:"MGC125865" OR ABSTRACT:"MGC125865") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RIT1, not a curated reading list.
Shares Comprehensive molecular profiling of lung adenocarcinoma, CIViC, Non-small-cell lung cancer.
Shares Comprehensive molecular profiling of lung adenocarcinoma, Non-small-cell lung cancer.
Shares Comprehensive molecular profiling of lung adenocarcinoma, Non-small-cell lung cancer.
Shares Comprehensive molecular profiling of lung adenocarcinoma, Non-small-cell lung cancer.
Shares Comprehensive molecular profiling of lung adenocarcinoma, Non-small-cell lung cancer.
Shares Comprehensive molecular profiling of lung adenocarcinoma, Non-small-cell lung cancer.
Shares Comprehensive molecular profiling of lung adenocarcinoma, Non-small-cell lung cancer.
Shares Comprehensive molecular profiling of lung adenocarcinoma, CIViC, Non-small-cell lung cancer.