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RIT1 (GTP-binding protein Rit1) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Endometrial cancer and Non-small-cell lung cancer. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Plays a crucial role in coupling nerve growth factor (NGF) stimulation to the activation of both EPHB2 and MAPK14 signalling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signalling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation. Recognised by LZTR1, which mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. Location: Cell membrane (UniProt). Locus 1q22 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"RIT1" OR ABSTRACT:"RIT1" OR TITLE:"Ras like without CAAX 1" OR ABSTRACT:"Ras like without CAAX 1" OR TITLE:"GTP-binding protein Rit1" OR ABSTRACT:"GTP-binding protein Rit1" OR TITLE:"ROC1" OR ABSTRACT:"ROC1" OR TITLE:"MGC125864" OR ABSTRACT:"MGC125864" OR TITLE:"MGC125865" OR ABSTRACT:"MGC125865") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RIT1, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/rit1.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/rit1.json. Licence CC BY-NC 4.0.