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RAD54L (DNA repair and recombination protein RAD54-like) is an enzyme. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
Multifunctional ATPase that plays a role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks. Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism. Also plays an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognised.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Olaparib. Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.91, animal model 0.55, genetic association 0.76, somatic mutation 0.55).
In plain words · RAD54L (DNA repair and recombination protein RAD54-like) is an enzyme. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
RAD54L (DNA repair and recombination protein RAD54-like) is an enzyme. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
Multifunctional ATPase that plays a role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks.
No product in this corpus aims at RAD54L yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker, dna-repair; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA RAD54L: RNA tissue enhanced (bone marrow 8 nTPM, lymphoid tissue 14 nTPM, testis 12 nTPM); blood lineage lineage enhanced (T-cells 1 nTPM); no normal tissue stained high; highest cancer staining thyroid cancer (2 of 4 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Prostate cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas RAD54L tissue; Open Targets ENSG00000085999 associations
First described 1996. Earliest sequence paper UniProt cites for the protein: Kanaar et al, Curr. Biol, 1996, "Human and mouse homologs of the Saccharomyces cerevisiae RAD54 DNA repair gene: evidence for functional conservation". Source.
Sources: HGNC HGNC:9826 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q92698 (protein name, function text, keywords and locations (REST API)); CIViC gene RAD54L (1 evidence items, 0 assertions, 1 variants; diseases: Castration-resistant Prostate Carcinoma (GraphQL API, CC0)); Open Targets ENSG00000085999 (association with cancer (MONDO_0004992) 0.56; (GraphQL API, CC0))
Multifunctional ATPase that plays a role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks. Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism. Also plays an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognised. Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA. Location: Nucleus (UniProt). Locus 1p34.1 (HGNC).
RNA: tissue enhanced (bone marrow 8 nTPM, lymphoid tissue 14 nTPM, testis 12 nTPM), detected in many normal tissues. Blood: lineage enhanced (T-cells 1 nTPM).
No normal tissue stained high.
Medium only: breast cancer, carcinoid, cervical cancer, endometrial cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"RAD54L" OR ABSTRACT:"RAD54L" OR TITLE:"RAD54 like" OR ABSTRACT:"RAD54 like" OR TITLE:"DNA repair and recombination protein RAD54-like" OR ABSTRACT:"DNA repair and recombination protein RAD54-like" OR TITLE:"hHR54" OR ABSTRACT:"hHR54" OR TITLE:"hRAD54" OR ABSTRACT:"hRAD54" OR TITLE:"RAD54A" OR ABSTRACT:"RAD54A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RAD54L, not a curated reading list.